The BaeSR two-component regulatory system mediates resistance to condensed tannins in Escherichia coli.
نویسندگان
چکیده
The gene expression profiles of Escherichia coli strains grown anaerobically with or without Acacia mearnsii (black wattle) extract were compared to identify tannin resistance strategies. The cell envelope stress protein gene spy and the multidrug transporter-encoding operon mdtABCD, both under the control of the BaeSR two-component regulatory system, were significantly up-regulated in the presence of tannins. BaeSR mutants were more tannin sensitive than their wild-type counterparts.
منابع مشابه
Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system.
The BaeSR two-component regulatory system controls expression of exporter genes conferring drug resistance in Escherichia coli (S. Nagakubo, K. Nishino, T. Hirata, and A. Yamaguchi, J. Bacteriol. 184:4161-4167, 2002; N. Baranova and H. Nikaido, J. Bacteriol. 184:4168-4176, 2002). To understand the whole picture of BaeSR regulation, a DNA microarray analysis of the effect of BaeR overproduction ...
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ورودعنوان ژورنال:
- Applied and environmental microbiology
دوره 74 2 شماره
صفحات -
تاریخ انتشار 2008